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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
The effect of the molecular weight of poly(I:C) on the development and behavior of offspring in the maternal immune activation model
 Cmarková, Nathalie ; Brožka, Hana (advisor) ; Petrásek, Tomáš (referee)
Maternal inflammation during pregnancy is associated with an increased risk of the development of psychiatric disorders in offspring, especially schizophrenia and autism. Prenatal treatment with poly(I:C), a viral mimetic, is a widely used model of maternal immune activation leading to developmental and behavioral alterations in offspring. However, results of studies are inconsistent possibly due to the differences in the molecular weight of used poly(I:C). In this thesis, the effect of different molecular weights of poly(I:C) was assessed. Pregnant Wistar rat females were treated by either high molecular weight (HMW) or low molecular weight (LMW) poly(I:C) on gestational day 14 to assess developmental and behavioral deficits relevant to schizophrenia and autism in offspring on postnatal day 12 and at three months. Prenatal exposition to the HMW poly(I:C) led to significantly reduced social behavior in the Homing test and a trend towards reduced USV vocalization in pups. The LMW pups showed significantly impaired negative geotaxis. In adulthood, the HMW and LMW offspring both exhibited significant social deficits and reduced anxiety. Anxiety was reduced mainly in the LMW group. This thesis revealed differences in behavioral outcomes between prenatal exposition to HMW and LMW poly(I:C). These...
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Obesity and psychiatric diseases
 Pluhařová, Apolena ; Matoulek, Martin (advisor) ; Karbanová, Martina (referee)
Introduction: Obesity is closely related to psychiatric disorders. I examined a sample of obese patients who were on VLCD / LCD during hospitalization. The aim was to determine the incidence of psychiatric disorders among obese patients and the development of their weight. Methods: Quantitative research was carried out at the D3 department at III. Department of Internal Medicine, 1st Faculty of Medicine, Charles University and General Faculty Hospital in Prague. The data for the research was obtained from medical reports of patients on VLCD / LCD during hospitalization in the period 2018-2019. The results were compared with the Czech population and professional literature. Results: Data analysis shows that 42.2 % of women and 26.2 % of men in the sample suffer from a psychiatric diagnosis. The most common psychiatric disorder was depression and anxiety. The result of a comparison of a sample of patients on VLCD with the Czech population indicate that there is a similar proportion of depressive disorder among women on VLCD and individuals with obesity in the rest of the Czech population. In men, there is less incidence of depression on VLCD patients than in the rest of the population. A lower incidence of depressive disorder in men may be because individuals with severe psychiatric conditions are...
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